GSK1120212 (JTP-74057) Is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained <i>In Vivo</i> Pathway Inhibition

Aidan G. Gilmartin, Maureen R. Bleam, Arthur Groy, +11

Clinical Cancer Research

The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4

Li Liu, Patrick A. Mayes, Stephen D. Eastman, +12

Clinical Cancer Research

Dabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin Lesions

Alastair J. King, Marc R. Arnone, Maureen R. Bleam, +12

PLoS ONE

DermatologyTumor BiologySignaling PathwayReceptor Tyrosine KinasePreclinical Characterization +15

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

Aidan G. Gilmartin, Thomas Faitg, Mark C. Richter, +24

Nature Chemical Biology

Proteinlipid InteractionProtein FunctionSignal TransductionFlap-subdomain InteractionBiochemistry +6

The dynamic processivity of the T4 DNA polymerase during replication

Jingsong Yang, Zhihao Zhuang, Rosa Maria Roccasecca, +2

Proceedings of the National Academy of Sciences

ChromatinT4 ReplisomeBiochemistryProtein FoldingViral Polymerase Mechanism +12

Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site

Jingsong Yang, Nino Campobasso, Mangatt P. Biju, +27

Chemistry & Biology

Signal TransductionCell SignalingMyristoyl Binding SiteNatural SciencesMacromolecular Machine +9

GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models

Mary Ann Hardwicke, Catherine A. Oleykowski, Ramona Plant, +10

Molecular Cancer Therapeutics

Aurora ACell DeathCancer BiologyTissue Culture CellsTumor Biology +14

Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase

Nicholas D. Adams, Jerry L. Adams, Joelle L. Burgess, +29

Journal of Medicinal Chemistry

Aurora B/c KinaseChemoprevention StrategyMolecular BiologyTumor BiologyMolecular Pharmacology +19

The Control Mechanism for Lagging Strand Polymerase Recycling during Bacteriophage T4 DNA Replication

Jingsong Yang, Scott W. Nelson, Stephen J. Benkovic

Molecular Cell

Natural SciencesViral Polymerase MechanismBacteriophageDna ReplicationMolecular Biology +4

Belantamab Mafodotin (GSK2857916) Drives Immunogenic Cell Death and Immune-mediated Antitumor Responses<i>In Vivo</i>

Rocío Montes de, Alireza Alavi, Nick Vitali, +27

Molecular Cancer Therapeutics