Michael E. Brune

Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

Gang Zhao, Andrew J. Souers, Martin J. Voorbach et al. · Journal of Medicinal Chemistry · 2008 · 140 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Identification of 2-(4-Benzyloxyphenyl)-<i>N</i>- [1-(2-pyrrolidin-1-yl-ethyl)-1<i>H</i>-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity

Andrew J. Souers, Ju Gao, Michael E. Brune et al. · Journal of Medicinal Chemistry · 2005 · 89 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and Metabolic Stabilization of Potent and Selective 2-Amino-<i>N</i>-(adamant-2-yl) Acetamide 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

Jeffrey J. Rohde, Marina Pliushchev, Bryan K. Sorensen et al. · Journal of Medicinal Chemistry · 2006 · 77 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors

Bryan K. Sorensen, Martin Winn, Jeff Rohde et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 64 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +3

Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists

Zhili Xin, Michael D. Serby, Hongyu Zhao et al. · Journal of Medicinal Chemistry · 2006 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17