Christine Orr

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Michael Degtyarev, Ann De Mazière, Christine Orr et al. · The Journal of Cell Biology · 2008 · 410 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Georgia Hatzivassiliou, Jacob R. Haling, Huifen Chen et al. · Nature · 2013 · 320 citations

Medicine, Cancer Biology, Oncology +14

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

Martin L. Sos, Stefanie Fischer, Roland T. Ullrich et al. · Proceedings of the National Academy of Sciences · 2009 · 256 citations · Full text

Medicine, Genetics, Oncology +17

Intermittent Administration of MEK Inhibitor GDC-0973 plus PI3K Inhibitor GDC-0941 Triggers Robust Apoptosis and Tumor Growth Inhibition

Klaus P. Hoeflich, Mark Merchant, Christine Orr et al. · Cancer Research · 2011 · 244 citations · Full text

Medicine, Oncology, Pharmacology +17

Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial

Denice S. Feig, Lois Donovan, Bernard Zinman et al. · The Lancet Diabetes & Endocrinology · 2020 · 228 citations · Full text

Medicine, Endocrinology, Obstetrics +14