Douglas B. Dixon

Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist.

Terry J. Opgenorth, Andrew Adler, Samuel V. Calzadilla et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 210 citations

Medicine, Pharmacology, Physiology +15

New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade

Joel B. Nelson, Son Hoang Nguyen, Jinshyun R. Wu‐Wong et al. · Urology · 1999 · 168 citations

Medicine, Cancer Biology, Endocrinology +13

Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells.

Edward F. Plow, Joseph C. Loftus, Eugene G. Levin et al. · Proceedings of the National Academy of Sciences · 1986 · 148 citations

Life Sciences, Cell Biology, Molecular Biology +12

2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ET_A Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722

Martin Winn, Thomas W von Geldern, Terry J. Opgenorth et al. · Journal of Medicinal Chemistry · 1996 · 113 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ET_B Selectivity

Thomas W von Geldern, Andrew S. Tasker, Bryan K. Sorensen et al. · Journal of Medicinal Chemistry · 1999 · 90 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17