Joseph C. Loftus

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

Sean P. Palecek, Joseph C. Loftus, Mark H. Ginsberg et al. · Nature · 1997 · 1.4K citations

Cell Migration Speed, Cell Adhesion, Cell Trafficking +9

Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)

Xiaoping Du, Edward F. Plow, Andrew L. Frelinger et al. · Cell · 1991 · 490 citations

Thrombosis, Signal Transduction, Blood Platelet +7

A β ₃ Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation

Joseph C. Loftus, Timothy E. O’Toole, Edward F. Plow et al. · Science · 1990 · 410 citations

Cytoadhesins, Integrins, and Platelets

Mark H. Ginsberg, Joseph C. Loftus, Edward F. Plow · Thrombosis and Haemostasis · 1988 · 301 citations

Thrombopoiesis, Thrombosis, Blood Platelet +5

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

Timothy E. O’Toole, Joseph C. Loftus, Xinping Du et al. · Cell Regulation · 1990 · 280 citations · Full text

Immunology, Integrin Function, Cellular Physiology +18