Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, +23

Nature Medicine

ObesityMetabolic SyndromeBiochemistryDiabetesPhysiology +8

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

Hiroshi Iwata, Claudia Goettsch, Amitabh Sharma, +16

Nature Communications

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

Yoshimi Nakagawa, Hitoshi Shimano, Tomohiro Yoshikawa, +13

Nature Medicine

Metabolic SyndromeTranscriptional RegulationSystems BiologySignal TransductionSignaling Pathway +11

p53 Involvement in the Pathogenesis of Fatty Liver Disease

Naoya Yahagi, Hitoshi Shimano, Takashi Matsuzaka, +17

Journal of Biological Chemistry

Protein Kinase A Suppresses Sterol Regulatory Element-binding Protein-1C Expression via Phosphorylation of Liver X Receptor in the Liver

Takashi Yamamoto, Hitoshi Shimano, Noriyuki Inoue, +8

Journal of Biological Chemistry

Fatty Liver DiseasePka Inhibitory EffectLiver X ReceptorSignaling PathwayFatty Acids +17

Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

Mayumi Ishikawa, Yuko Iwasaki, Shigeru Yatoh, +11

Journal of Lipid Research

Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance

Noriyuki Inoue, Naoya Yahagi, Takashi Yamamoto, +12

Journal of Biological Chemistry

Distinct Effects of Pravastatin, Atorvastatin, and Simvastatin on Insulin Secretion from a β-cell Line, MIN6 Cells

Mayumi Ishikawa, Fuminori Okajima, Noriyuki Inoue, +6

Journal of Atherosclerosis and Thrombosis

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status

Hirohito Sone, Hitoshi Shimano, Yuki Sakakura, +11

American Journal of Physiology-Endocrinology and Metabolism

Srebp BindingGeneticsMolecular BiologyFatty Liver DiseaseInsulin Signaling +20

Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis Correlation with disease activity

Hirohito Sone, Michihiro Sakauchi, Akimitsu Takahashi, +9

Life Sciences

InflammationRheumatologyRheumatoid DisorderVasculitisAutoimmune Disease +12