Arno L. Greenleaf

A Novel Domain in Set2 Mediates RNA Polymerase II Interaction and Couples Histone H3 K36 Methylation with Transcript Elongation

Kelby O. Kizer, Hemali Phatnani, Yoichiro Shibata et al. · Molecular and Cellular Biology · 2005 · 503 citations · Full text

Histone Modifications, Transcript Elongation, Epigenetic Change +22

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

Bartlomiej Bartkowiak, Pengda Liu, Hemali Phatnani et al. · Genes & Development · 2010 · 395 citations · Full text

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Tinghu Zhang, Nicholas Kwiatkowski, Sarah E. Dixon-Clarke et al. · Nature Chemical Biology · 2016 · 356 citations · Full text

Drug Target, Drug Targeting, Biochemistry +10

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

Thomas O’Brien, S. E. Hardin, Arno L. Greenleaf et al. · Nature · 1994 · 326 citations

Transcriptional Regulation, Natural Sciences, Rna Binding Proteins +10

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Małgorzata Krajewska, Ruben Dries, Andrew V. Grassetti et al. · Nature Communications · 2019 · 257 citations · Full text