Thomas O’Brien

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Anneleen Daemen, David Peterson, Nisebita Sahu et al. · Proceedings of the National Academy of Sciences · 2015 · 403 citations · Full text

Metabolomic Profiling, Pathology, Metabolic Remodeling +24

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

Paola Magnaghi, Roberto D’Alessio, Barbara Valsasina et al. · Nature Chemical Biology · 2013 · 380 citations

Biochemistry, Medicine, Natural Sciences +10

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

Thomas O’Brien, S. E. Hardin, Arno L. Greenleaf et al. · Nature · 1994 · 326 citations

Transcriptional Regulation, Natural Sciences, Rna Binding Proteins +10

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

Christy C. Ong, Adrian M. Jubb, Peter M. Haverty et al. · Proceedings of the National Academy of Sciences · 2011 · 253 citations

Apoptosis, Cell Death, Tumor Cells +18

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau, Hans E. Purkey, A. Hitz et al. · Nature Chemical Biology · 2016 · 251 citations · Full text

Systems Biology, Biochemistry, Ldha Inhibition +8