Thomas O’Brien - Concepedia

Author

Thomas O’Brien

Also Known As

O’Brien, Thomas, T O'Brien, T OBRIEN, T O’Brien, T. O'Brien, T. Obrien, T. O’Brien, Thomas O'Brien, Thomas O’Brien, Tina M. O'Brien

103

Publications

6.5K

Citations

H-Index

130

Concepts

All Affiliations

Sunesis (United States)Forma Therapeutics (United States)Cornell University University of California, Berkeley

About

Thomas O’Brien is an author at Sunesis (United States) specializing in medicine, pharmacology, and natural sciences.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	33	42	4.2K
2	Natural Sciences	20	21	2.2K
3	Engineering	2	2	118
4	Health Sciences	1	1	403
5	Management	1	1	20

Thomas O’Brien

Publications

5.3K

Citations

H-Index

Page 1

	Year	Citations
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors Anneleen Daemen, David Peterson, Nisebita Sahu, Proceedings of the National Academy of Sciences Metabolomic ProfilingPathologyMetabolic RemodelingPdac Clinical SamplesTumor Biology	2015	403
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death Paola Magnaghi, Roberto D’Alessio, Barbara Valsasina, Nature Chemical Biology BiochemistryMedicineNatural SciencesApoptosisCell Death	2013	380
Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation Thomas O’Brien, S. E. Hardin, Arno L. Greenleaf, Nature Transcriptional RegulationNatural SciencesRna Binding ProteinsTranscriptional ElongationRna Biology	1994	326
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells Christy C. Ong, Adrian M. Jubb, Peter M. Haverty, Proceedings of the National Academy of Sciences ApoptosisCell DeathTumor CellsCancer BiologyTumor Biology	2011	253
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition Aaron Boudreau, Hans E. Purkey, A. Hitz, Nature Chemical Biology Systems BiologyBiochemistryLdha InhibitionLipid PeroxidationMetabolic Regulation	2016	251
Discovery of an allosteric site in the caspases Jeanne A. Hardy, Joni W. Lam, Jack Nguyen, Proceedings of the National Academy of Sciences Protein AssemblyMolecular BiologyChemical BiologyUnicellular OrganismBiochemical Taxonomy	2004	241
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism Maša Ždralević, Almut Brand, Lorenza Di Ianni, Journal of Biological Chemistry Tumor BiologyBiochemistryMedicineTumor GrowthLactate Dehydrogenases	2018	239
In situ assembly of enzyme inhibitors using extended tethering Daniel A. Erlanson, Joni W. Lam, Christian Wiesmann, Nature Biotechnology BiochemistryNatural SciencesBioconjugationImmobilized EnzymeProtein Engineering	2003	196
Rapid changes in Drosophila transcription after an instantaneous heat shock. Thomas O’Brien, John T. Lis Molecular and Cellular Biology Molecular RegulationGeneticsMolecular BiologyDrosophila TranscriptionMolecular Genetics	1993	164
Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes John P. McGrath, Kaylyn E. Williamson, Srividya Balasubramanian, Cancer Research Histone ModificationsMixed-phenotype Acute LeukemiaEpigenetic ChangePharmacological InhibitionEpigenetics	2016	123

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