Thomas O’Brien

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Anneleen Daemen, David Peterson, Nisebita Sahu et al. · Proceedings of the National Academy of Sciences · 2015 · 418 citations · Full text

Medicine, Biochemistry, Oncology +17

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

Thomas O’Brien, S. E. Hardin, Arno L. Greenleaf et al. · Nature · 1994 · 327 citations

Life Sciences, Biochemistry, Molecular Biology +14

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau, Hans E. Purkey, A. Hitz et al. · Nature Chemical Biology · 2016 · 268 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism

Maša Ždralević, Almut Brand, Lorenza Di Ianni et al. · Journal of Biological Chemistry · 2018 · 255 citations · Full text

Life Sciences, Cancer Biology, Genetics +16

Rapid changes in Drosophila transcription after an instantaneous heat shock.

Thomas O’Brien, John T. Lis · Molecular and Cellular Biology · 1993 · 164 citations · Full text

Life Sciences, Genetics, Molecular Biology +17