An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site

Fernando Rock, Weimin Mao, A. Yaremchuk, +13

Science

EngineeringCorrect Amino AcidAminoacyl-trna SynthetaseMolecular BiologyEditing Site +17

Design, Activity, and 2.8 Å Crystal Structure of a <i>C</i> ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

John W. Erickson, David J. Neidhart, John H. VanDrie, +12

Science

ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

Hing L. Sham, Dale J. Kempf, Akhteruzammen Molla, +24

Antimicrobial Agents and Chemotherapy

Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

Stephen J. Baker, Yong-Kang Zhang, Tsutomu Akama, +7

Journal of Medicinal Chemistry

5-Fluoro-1,3-dihydro-1-hydroxy-2,1- BenzoxaboroleMedicinal ChemistryAntifungal AgentAntifungal AgentsMedicine +9

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

Robert T. Jacobs, Bakela Nare, Stephen A. Wring, +24

PLoS neglected tropical diseases

Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

Tsutomu Akama, Stephen J. Baker, Yongkang Zhang, +7

Bioorganic & Medicinal Chemistry Letters

InflammationMedicinal ChemistryAnti-inflammatoryAtopic DermatitisMedicine +7

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy

Dale J. Kempf, Hing L. Sham, Kennan C. Marsh, +15

Journal of Medicinal Chemistry

ImmunologyPharmacotherapyAntiviral DrugPharmaceutical ChemistryDrug Resistance +16

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

Vincent Hernandez, Thibaut Crépin, Andrés Palencia, +32

Antimicrobial Agents and Chemotherapy

Available AntibioticsMicrobial PathogensLead AnalogueBoron-based AntibacterialsAntimicrobial Chemotherapy +22

A synthesis of protected aminoalkyl epoxides from .alpha.-amino acids

Jay R. Luly, Joseph F. Dellaria, Jacob J. Plattner, +2

The Journal of Organic Chemistry

.Alpha.-amino AcidsBioorganic ChemistryBiochemistryDonut IconNatural Sciences +8

Human Serum Attenuates the Activity of Protease Inhibitors toward Wild-Type and Mutant Human Immunodeficiency Virus

Akhteruzzaman Molla, Sudthida Vasavanonda, Gondi Kumar, +9

Virology

Protease InhibitorsBiochemistryMedicineNatural SciencesHuman Retrovirus +11