Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

Stephen J. Baker, Yong-Kang Zhang, Tsutomu Akama, +7

Journal of Medicinal Chemistry

5-Fluoro-1,3-dihydro-1-hydroxy-2,1- BenzoxaboroleMedicinal ChemistryAntifungal AgentAntifungal AgentsMedicine +9

Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents

Dazhong Ding, Yaxue Zhao, Qingqing Meng, +16

ACS Medicinal Chemistry Letters

Medicinal ChemistryAntimicrobial Drug DiscoveryCentral Linkage GroupsBiochemistryAntiparasitic Agent +12

Benzoxaboroles: A New Class of Potential Drugs for Human African Trypanosomiasis

Robert T. Jacobs, Jacob J. Plattner, Bakela Nare, +13

Future Medicinal Chemistry

Lead CompoundsBioorganic ChemistryAntiparasitic AgentMalariaPathology +15

Synthesis and structure–activity relationships of novel benzoxaboroles as a new class of antimalarial agents

Yong-Kang Zhang, Jacob J. Plattner, Yvonne R. Freund, +14

Bioorganic & Medicinal Chemistry Letters

Novel BenzoxaborolesAntiparasitic AgentMedicineNew ClassChemistry +4

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

Yong-Kang Zhang, Jacob J. Plattner, Eric E. Easom, +11

Journal of Medicinal Chemistry

Combinatorial ChemistryAntiparasitic AgentMalariaImmunologyChemistry +16

Dynamic Receptor-dependent Activation of Inducible Nitric-oxide Synthase by ERK-mediated Phosphorylation of Ser745

Yong-Kang Zhang, Viktor Brovkovych, Svitlana D. Brovkovych, +4

Journal of Biological Chemistry

Nitric OxideImmunologyInos ActivityInflammationErk-mediated Phosphorylation +18

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

Yong-Kang Zhang, Jacob J. Plattner, Yvonne R. Freund, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAntiparasitic AgentMedicineBenzoxaborole Antimalarial AgentsPharmacology +2

Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease

Charles Z. Ding, Yong-Kang Zhang, Xianfeng Li, +18

Bioorganic & Medicinal Chemistry Letters

BiochemistryBiological EvaluationsMedicineAntiviral Drug DevelopmentAntiviral Therapy +6

Synthesis and evaluation of novel α-amino cyclic boronates as inhibitors of HCV NS3 protease

Xianfeng Li, Yong-Kang Zhang, Yang Liu, +30

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesAntiviral Drug Development +7

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Tsutomu Akama, Yong-Kang Zhang, Yvonne R. Freund, +15

Bioorganic & Medicinal Chemistry Letters