An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site

Fernando Rock, Weimin Mao, A. Yaremchuk, +13

Science

EngineeringCorrect Amino AcidAminoacyl-trna SynthetaseMolecular BiologyEditing Site +17

Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

Stephen J. Baker, Yong-Kang Zhang, Tsutomu Akama, +7

Journal of Medicinal Chemistry

5-Fluoro-1,3-dihydro-1-hydroxy-2,1- BenzoxaboroleMedicinal ChemistryAntifungal AgentAntifungal AgentsMedicine +9

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

Robert T. Jacobs, Bakela Nare, Stephen A. Wring, +24

PLoS neglected tropical diseases

Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

Tsutomu Akama, Stephen J. Baker, Yongkang Zhang, +7

Bioorganic & Medicinal Chemistry Letters

InflammationMedicinal ChemistryAnti-inflammatoryAtopic DermatitisMedicine +7

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

Vincent Hernandez, Thibaut Crépin, Andrés Palencia, +32

Antimicrobial Agents and Chemotherapy

Available AntibioticsMicrobial PathogensLead AnalogueBoron-based AntibacterialsAntimicrobial Chemotherapy +22

In Vitro Penetration of a Novel Oxaborole Antifungal (AN2690) Into the Human Nail Plate

Xiaoying Hui, Stephen J. Baker, Ronald C. Wester, +8

Journal of Pharmaceutical Sciences

Antifungal AgentHuman Nail PlateAntifungal AgentsPharmacologyNovel Oxaborole Antifungal +3

Identification of Borinic Esters as Inhibitors of Bacterial Cell Growth and Bacterial Methyltransferases, CcrM and MenH

Stephen J. Benkovic, Stephen J. Baker, M.R. Alley, +10

Journal of Medicinal Chemistry

Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

Yvonne R. Freund, Tsutomu Akama, M.R. Alley, +12

FEBS Letters

Pharmaceutical SciencePhosphodiesterase 4PharmacotherapyChemical BiologyBoron-based Molecules +19

UCS1025A and B, New Antitumor Antibiotics from the Fungus <i>Acremonium</i> Species

Tsutomu Agatsuma, Tsutomu Akama, Shinji Nara, +7

Organic Letters

New Antitumor AntibioticsMedicinal FungiOrganic ChemistryAntimicrobial ChemotherapyHeterocycle Chemistry +18

Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes

Dong Chen, Charlotte Virtucio, Olga Zemska, +9

Journal of Pharmacology and Experimental Therapeutics