Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors

Noel D. D’Angelo, Steven F. Bellon, Shon K. Booker, +23

Journal of Medicinal Chemistry

Molecular DockingMedicinal ChemistryDrug TargetPotent C-met InhibitorsBiochemistry +11

Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1<i>H</i>-benzimidazoles

Vassil I. Ognyanov, Balan Chenera, Anthony W. Bannon, +15

Journal of Medicinal Chemistry

Drug TargetPain MedicineNeuropathic PainMolecular PainCompound 46Ad +19

Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold

Brad Herberich, Guoqiang Cao, Partha Chakrabarti, +21

Journal of Medicinal Chemistry

Synthesis of Polyfunctionalized Quinolines via the Sequence of Propargyl–Allenyl Isomerization and Aza-electrocyclization

Hongwei Zhou, Le Liu, Shimin Xu

The Journal of Organic Chemistry

Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core

Ning Xi, Clarence Hale, Michael Kelly, +5

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologySuccinamide CoreFunctional SelectivityMedicineMolecular Biology +6

Discovery and Evaluation of 7-Alkyl-1,5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein Kinase^⊥⊥ Atomic coordinates and structure factors for crystal structure of compound<b>3d</b>with p38α can be accessed using PDB code 3LHJ.

Liping H. Pettus, Ryan P. Wurz, Shimin Xu, +14

Journal of Medicinal Chemistry

Crystal StructureDrug TargetImmunologyCell DeathChemical Biology +24

3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase

Liping H. Pettus, Shimin Xu, Guoqiang Cao, +18

Journal of Medicinal Chemistry

Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists

Ning Xi, Yunxin Bo, Elizabeth M. Doherty, +10

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicinePharmacological AgentThiazole Carboxamides +3

N-Aryl-γ-lactams as integrin αvβ3 antagonists

Ning Xi, Stephen Arvedson, S.W.E. Eisenberg, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentPharmacotherapyPharmacology +4

Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Ryan P. Wurz, Liping H. Pettus, Shimin Xu, +12

Bioorganic & Medicinal Chemistry Letters

Structure–activity RelationshipPart 1Drug TargetBiochemistryMedicine +5