A Designed Peptide Ligase for Total Synthesis of Ribonuclease A with Unnatural Catalytic Residues

David Y. Jackson, John P. Burnier, Clifford Quan, +3

Science

Bioorganic ChemistryEngineeringEngineered VariantPeptide EngineeringMolecular Biology +16

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Ingrid E. Wertz, Kim Newton, Dhaya Seshasayee, +31

Nature

InflammationAnti-inflammatoryAutoimmune DiseaseMedicineImmunology +5

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

John A. Flygare, Maureen H. Beresini, Nageshwar Budha, +39

Journal of Medicinal Chemistry

ApoptosisCell DeathClinical CandidatePharmacotherapyImmunotherapeutics +18

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

Xiaolei Ma, Elizabeth Helgason, Qui Phung, +6

Proceedings of the National Academy of Sciences

Immune RegulationImmunologyTank-binding KinaseInnate ImmunityCellular Physiology +19

Novel Peptides Selected to Bind Vascular Endothelial Growth Factor Target the Receptor-Binding Site

Wayne J. Fairbrother, Hans W. Christinger, Andrea G. Cochran, +7

Biochemistry

Analysis of PDZ Domain-Ligand Interactions Using Carboxyl-terminal Phage Display

Germaine Fuh, M. Teresa Pisabarro, Ying Li, +3

Journal of Biological Chemistry

Pdz DomainSystems BiologySignal TransductionBiochemistryProtein Folding +11

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

Yingnan Zhang, Charles Eigenbrot, Lijuan Zhou, +10

Journal of Biological Chemistry

Signal TransductionBiochemistryPeptide LibraryImmunologySmall Peptide +4

Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

Toru Okamoto, Kerry Zobel, Anna Fedorova, +7

ACS Chemical Biology

Therapeutic PeptidesPeptide EngineeringApoptosisMolecular BiologyCell Death +19

A Key Claudin Extracellular Loop Domain is Critical for Epithelial Barrier Integrity

Randall J. Mrsny, G. Thomas Brown, Kirsten Gerner-Smidt, +5

American Journal Of Pathology

Epithelial Barrier IntegritySignal TransductionSignaling PathwayCell SignalingCell Adhesion +12

X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.

Charles Eigenbrot, M. Randal, Clifford Quan, +4

PubMed