Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E. Wertz, Saritha Kusam, Cynthia Lam, +24

Nature

Protein FunctionMedicineImmune Checkpoint InhibitorCancer BiologyCytoskeleton +7

c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling

Jasmin N. Dynek, Tatiana Goncharov, Erin C. Dueber, +8

The EMBO Journal

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Ingrid E. Wertz, Kim Newton, Dhaya Seshasayee, +31

Nature

InflammationAnti-inflammatoryAutoimmune DiseaseMedicineImmunology +5

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

Xiaolei Ma, Elizabeth Helgason, Qui Phung, +6

Proceedings of the National Academy of Sciences

Immune RegulationImmunologyTank-binding KinaseInnate ImmunityCellular Physiology +19

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7

Yingnan Zhang, Lijuan Zhou, Lionel Rougé, +8

Nature Chemical Biology

Conformational StabilizationProtein FunctionBiochemistryUbiquitin Yields PotentMedicine +6

Preparation of Distinct Ubiquitin Chain Reagents of High Purity and Yield

Ken C. Dong, Elizabeth Helgason, Christine Yu, +9

Structure

EngineeringBiochemistryHigh PurityBiotechnologyBiomolecular Engineering

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling

Aaron H. Phillips, Yingnan Zhang, Christian N. Cunningham, +11

Proceedings of the National Academy of Sciences

A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands

Micah Steffek, Elizabeth Helgason, Nataliya Popovych, +23

Biochemistry

MitophagyMolecular BiologyChemistryChemical BiologySmall-molecule Ligands +16

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein

Willem den Besten, Kshitij Verma, Sayumi Yamazoe, +13

Journal of the American Chemical Society

Protein AssemblyApoptosis ProteinXiap Bir2ApoptosisXiap Binders +21

Constitutive protein degradation induces acute cell death via proteolysis products

Sihan Chen, Sumit Prakash, Elizabeth Helgason, +12