Giles A. Brown - Concepedia

Author

Giles A. Brown

Heptares Therapeutics (United Kingdom)

Also Known As

Brown, Giles A, Giles A Brown, Giles A. Brown, Giles Brown

Publications

1.1K

Citations

H-Index

Concepts

All Affiliations

Heptares Therapeutics (United Kingdom)AstraZeneca (United Kingdom)University of Bristol University of Cambridge AstraZeneca (United States)

About

Giles A. Brown is an author at Heptares Therapeutics (United Kingdom) specializing in pharmacology, biochemistry, and biomolecular engineering.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Biochemistry	6	6	380
2	Medicine	5	5	441
3	Natural Sciences	5	5	345
4	Biomolecular Engineering	5	5	206
5	Engineering	4	4	171

Giles A. Brown

Publications

913

Citations

H-Index

Page 1

	Year	Citations
Structural insight into allosteric modulation of protease-activated receptor 2 R.K. Cheng, Cédric Fiez-Vandal, Oliver Schlenker, Nature Signal TransductionBiochemistryG Protein-coupled ReceptorNatural SciencesMedicine	2017	246
Small molecule AZD4635 inhibitor of A<sub>2A</sub>R signaling rescues immune cell function including CD103<sup>+</sup> dendritic cells enhancing anti-tumor immunity Alexandra Borodovsky, Christine M. Barbon, Yanjun Wang, Journal for ImmunoTherapy of Cancer	2020	96
Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals Prakash Rucktooa, R.K. Cheng, Elena Segala, Scientific Reports	2018	92
From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease Alastair Brown, Sophie J. Bradley, Fiona H. Marshall, Cell Molecular PharmacologyNeurodegenerative DiseasesAlzheimer's DiseaseMedicineMechanism Of Action	2021	87
Sequenced Reactions with Samarium(II) Iodide. Sequential Intramolecular Barbier Cyclization/Grob Fragmentation for the Synthesis of Medium-Sized Carbocycles Gary A. Molander, Yvan Le Huérou, Giles A. Brown The Journal of Organic Chemistry Asymmetric CatalysisCross-coupling ReactionEngineeringHeterocyclicOrganic Chemistry	2001	77
Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target Dean G. Brown, Giles A. Brown SLAS DISCOVERY Chemical BiologyPar2 ProteinDrug TargetProtease-activated Receptor 2Biochemistry	2018	49
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Nature Communications	2021	43
Sequenced Reactions with Samarium(II) Iodide. Sequential Intramolecular Reformatsky/Nucleophilic Acyl Substitution Reactions for the Synthesis of Medium-Sized Carbocycles Gary A. Molander, Giles A. Brown, I. Gràcia The Journal of Organic Chemistry Cross-coupling ReactionNine-membered CarbocyclesEngineeringHeterocyclicReformatsky Reaction	2002	42
The azomethine ylide strategy for β-lactam synthesis. Azapenams and 1-azacephams David Brown, Giles A. Brown, Mark D. Andrews, Journal of the Chemical Society Perkin Transactions 1 β-Lactam-based Oxazolidinone 5EngineeringRing SystemHeterocyclicMedicine	2002	37
The Azomethine Ylid Strategy in β-Lactam Synthesis. Application to Selenapenams Giles A. Brown, K.M. Anderson, Martin Murray, Tetrahedron BiochemistryAzomethine Ylid StrategyPharmacologyPharmaceutical ChemistrySynthetic Chemistry	2000	35

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