Giles A. Brown

Structural insight into allosteric modulation of protease-activated receptor 2

R.K. Cheng, Cédric Fiez-Vandal, Oliver Schlenker et al. · Nature · 2017 · 253 citations

Life Sciences, Biochemistry, Molecular Biology +16

Small molecule AZD4635 inhibitor of A_2AR signaling rescues immune cell function including CD103⁺ dendritic cells enhancing anti-tumor immunity

Alexandra Borodovsky, Christine M. Barbon, Yanjun Wang et al. · Journal for ImmunoTherapy of Cancer · 2020 · 102 citations · Full text

Medicine, Immunology, Pharmacology +17

From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

Alastair Brown, Sophie J. Bradley, Fiona H. Marshall et al. · Cell · 2021 · 97 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

Prakash Rucktooa, R.K. Cheng, Elena Segala et al. · Scientific Reports · 2018 · 95 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Sequenced Reactions with Samarium(II) Iodide. Sequential Intramolecular Barbier Cyclization/Grob Fragmentation for the Synthesis of Medium-Sized Carbocycles

Gary A. Molander, Yvan Le Huérou, Giles A. Brown · The Journal of Organic Chemistry · 2001 · 78 citations

Natural Sciences, Chemistry, Catalysis +9