Alastair Brown

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

Mohamed S. Zaïbi, Claire J. Stocker, Jacqueline O’Dowd et al. · FEBS Letters · 2010 · 330 citations

Gpr41 Knockout Mice, Murine Adipose Tissue, Leptin Secretion +21

Extra-helical binding site of a glucagon receptor antagonist

Ali Jazayeri, A.S. Dore, Daniel Lamb et al. · Nature · 2016 · 224 citations

Molecular Pharmacology, Molecular Physiology, Biochemistry +7

Crystal structure of the GLP-1 receptor bound to a peptide agonist

Ali Jazayeri, Mathieu Rappas, Alastair Brown et al. · Nature · 2017 · 193 citations

Glp-1 Receptor Bound, Crystal Structure, Biochemistry +7

Differential Signaling by Splice Variants of the Human Free Fatty Acid Receptor GPR120

Sarah‐Jane Watson, Alastair Brown, Nicholas D. Holliday · Molecular Pharmacology · 2012 · 132 citations · Full text

From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

Alastair Brown, Sophie J. Bradley, Fiona H. Marshall et al. · Cell · 2021 · 87 citations · Full text

Molecular Pharmacology, Neurodegenerative Diseases, Alzheimer's Disease +10