Small molecule AZD4635 inhibitor of A_2AR signaling rescues immune cell function including CD103⁺ dendritic cells enhancing anti-tumor immunity

Abstract

We provide evidence implicating suppression of adaptive and innate immunity by adenosine as a mechanism for immune evasion by tumors. Inhibition of adenosine signaling through selective small molecule inhibition of A_2AR using AZD4635 restores T cell function via an internal mechanism as well as tumor antigen cross-presentation by CD103⁺ DCs resulting in antitumor immunity.