Concepedia

Adenosine-mediated Suppression

Adenosine-Mediated Suppression is an immunomodulatory mechanism within the broader category of T cell exhaustion, characterized by the inhibition of T cell function through the binding of extracellular adenosine to A2A and A2B receptors, thereby amplifying immunosuppressive signaling in the tumor microenvironment.

538

Publications

44.5K

Citations

3K

Authors

817

Institutions

Publications per year

2017–2026

121

Parents

Publications

538

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Silvia Deaglio, Karen M. Dwyer, Wenda Gao et al. · The Journal of Experimental Medicine · 2007 · 2.4K citations · Full text

, , +15

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

Giovanna Borsellino, Markus Kleinewietfeld, Diletta Di Mitri et al. · Blood · 2007 · 1.3K citations · Full text

, , +13

A2A adenosine receptor protects tumors from antitumor T cells

Akio Ohta, Elieser Gorelik, Simon J. Prasad et al. · Proceedings of the National Academy of Sciences · 2006 · 1K citations

, , +16

Adenosine inhibits IL‐12 and TNF‐α production via adenosine A <sub>2a</sub> receptor‐dependent and independent mechanisms

György Haskó, David G. Kuhel, Jiang‐Fan Chen et al. · The FASEB Journal · 2000 · 508 citations

, , +17

Adenosine: A potential mediator of seizure arrest and postictal refractoriness

M. J. During, Dennis D. Spencer · Annals of Neurology · 1992 · 477 citations

, , +13

1–5 of 538

Authors

3K

  1. JL
    Joel Linden

    University of Virginia, United States

    25 publications · 5.4K citations

    21

    h-index

  2. MV
    Michail V. Sitkovsky

    Northeastern University, United States

    15 publications · 2.6K citations

    14

    h-index

  3. EK
    Edwin K. Jackson

    University of Pittsburgh, United States

    11 publications · 2.3K citations

    11

    h-index

  4. JB
    Jonathan Blay

    Dalhousie University, Canada

    11 publications · 1.2K citations

    11

    h-index

  5. DW
    David W. Hoskin

    Dalhousie University, Canada

    10 publications · 1.2K citations

    10

    h-index

1–5 of 3K

Institutions

817

  1. University of Virginia

    Charlottesville, United States

    17 h-index

    68 publications

    10K citations

  2. Harvard University

    Cambridge, United States

    14 h-index

    48 publications

    6.7K citations

  3. National Institutes of Health

    Bethesda, United States

    14 h-index

    40 publications

    11.4K citations

  4. Dalhousie University

    Halifax, Canada

    12 h-index

    37 publications

    3.3K citations

  5. Beth Israel Deaconess Medical Center

    Boston, United States

    12 h-index

    47 publications

    6K citations

  6. Inserm

    Paris, France

    12 h-index

    64 publications

    11.2K citations

  7. Northeastern University

    Boston, United States

    12 h-index

    39 publications

    6.5K citations

  8. University of Pittsburgh

    Pittsburgh, United States

    12 h-index

    30 publications

    3.9K citations

1–8 of 817

Venues

  1. The Journal of Immunology

    JI · 37 publications · 5.1K citations

    33

    h-index

  2. PubMed

    Repository · 24 publications · 1.9K citations

    21

    h-index

  3. OncoImmunology

    12 publications · 1.1K citations

    12

    h-index

  4. European Journal of Immunology

    EJI · 11 publications · 1.1K citations

    11

    h-index

  5. Cancer Research

    13 publications · 1.4K citations

    11

    h-index

1–5