Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

Patrick H. Maxwell, Gabi U. Dachs, Jonathan Gleadle, +6

Proceedings of the National Academy of Sciences

AngiogenesisSolid TumorsHeterodimeric Transcription FactorMedicineTumor Growth +13

Identification of the renal erythropoietin-producing cells using transgenic mice

Patrick H. Maxwell, Mark Osmond, Christopher W. Pugh, +7

Kidney International

UrologyTransgenic MiceKidney Tubule RemodelingMedicineCell Biology +2

Abnormal Sympathoadrenal Development and Systemic Hypotension in <i>PHD3</i>^{<i>−</i>/<i>−</i>} Mice

Tammie Bishop, Denis Gallagher, Alberto Pascual, +20

Molecular and Cellular Biology

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway

Emma J. Hodson, Lynn G. Nicholls, Philip J. Turner, +9

The Journal of Physiology

Redox BiologyOxidative StressInflammationInducible InactivationRedox Regulator +15

Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection.

Peter J. Ratcliffe, Richard W. Jones, R E Phillips, +2

The Journal of Experimental Medicine

Rat Epo GeneIsolated KidneysOligonucleotide PrimersRedox BiologyOxidative Stress +19

The interstitial response to renal injury: Fibroblast–like cells show phenotypic changes and have reduced potential for erythropoietin gene expression

Patrick H. Maxwell, David Ferguson, Lynn G. Nicholls, +2

Kidney International

InflammationUrologyErythropoietin Gene ExpressionRenal FunctionRenal Pathology +11

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

Tammie Bishop, Nick P. Talbot, Philip J. Turner, +12

The Journal of Physiology

Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor

Emma C. Vaux, S. Morwenna Wood, Matthew E. Cockman, +5

Journal of Biological Chemistry

Effect of inhaled alpha-emitting nuclides on mouse alveolar macrophages.

R.J. Talbot, Lynn G. Nicholls, A. Morgan, +1

PubMed

AsthmaInflammatory Lung DiseaseLung InflammationImmunologyNuclear Abnormalities +14

Regulation of gene expression by oxygen levels in mammalian cells.

Christopher W. Pugh, Gu-Gang Chang, Matthew E. Cockman, +12

PubMed

Transcriptional RegulationDevelopmental BiologyRedox RegulatorHypoxia (Medicine)Tissue Oxygenation +7