Christopher W. Pugh

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

Life Sciences, Biochemistry, Molecular Biology +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

Medicine, Cancer Biology, Oncology +14

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +9

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Katherine Louise Talks, Helen Turley, Kevin C. Gatter et al. · American Journal Of Pathology · 2000 · 1.3K citations

Medicine, Cancer Biology, Oncology +16

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

Charles C. Wykoff, Nigel Beasley, Peter H. Watson et al. · PubMed · 2000 · 1.3K citations

Medicine, Cancer Biology, Oncology +17