Concepedia

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Katherine Louise Talks, Helen Turley, Kevin C. Gatter, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe, Adrian L. Harris

American Journal Of Pathology · 2000 · 1.3K citations · 39 references

DOI

Concepts

References

39

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

, , +14

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Peter Carmeliet, Yuval Dor, Jean-Marc Herbert et al. · Nature · 1998 · 2.5K citations

, , +16

Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α

Narayan V. Iyer, Lori E. Kotch, Faton Agani et al. · Genes & Development · 1998 · 2.5K citations · Full text

, , +16

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Hua Zhong, Angelo M. De Marzo, Erik Laughner et al. · PubMed · 1999 · 2.2K citations

, , +14