Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes

Zhihua Sui, Rafael Salto, Jia Li, +2

Bioorganic & Medicinal Chemistry

Hiv-2 ProteasesMedicinal ChemistryBiochemistryCurcumin Boron ComplexesNatural Sciences +8

MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage

Peter Kalev, Marc L. Hyer, Zenon Konteatis, +27

Cancer Cell

MedicineCancer GrowthCancer Cell BiologyMtap-deleted Cancer CellsCell Biology +7

Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma

Zenon Konteatis, Erin Artin, Brandon Nicolay, +25

ACS Medicinal Chemistry Letters

Mutant Isocitrate DehydrogenaseHigh-grade GliomasGliomaNeuro-oncologyMedicinal Chemistry +16

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

Anil K. Padyana, Lei Jin, Giovanni Cianchetta, +13

Nature Communications

Substituted Salicylanilides as Inhibitors of Two-Component Regulatory Systems in Bacteria

Mark J. Macielag, James P. Demers, Stephanie A. Fraga‐Spano, +12

Journal of Medicinal Chemistry

Bioorganic ChemistryAntibiotic AdjuvantAntimicrobial ChemotherapyChemical BiologyDrug Resistance +15

Pd-Catalyzed Direct Arylation of Tautomerizable Heterocycles with Aryl Boronic Acids via C−OH Bond Activation Using Phosphonium Salts

Fu‐An Kang, Zhihua Sui, William V. Murray

Journal of the American Chemical Society

Asymmetric CatalysisCross-coupling ReactionEngineeringBiochemistryPhosphonium Salts +13

Identification and Structure−Activity Relationships of Chromene-Derived Selective Estrogen Receptor Modulators for Treatment of Postmenopausal Symptoms

Nareshkumar Jain, Jiayi Xu, Ramesh M. Kanojia, +15

Journal of Medicinal Chemistry

Design, Synthesis, and in Vivo SAR of a Novel Series of Pyrazolines as Potent Selective Androgen Receptor Modulators

Xuqing Zhang, Xiaojie Li, George F. Allan, +4

Journal of Medicinal Chemistry

PharmacotherapyPharmaceutical ChemistryMedicinal ChemistryPharmacological StudyRadiation Oncology +16

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous <i>MTAP</i> Deletion

Zenon Konteatis, Jeremy Travins, Katya Marjon, +23

Journal of Medicinal Chemistry

1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2

Zhihua Sui, Jihua Guan, Michael P. Ferro, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacological Agent +6