Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

James Sutton, Scott A. Bolton, Karen S. Hartl, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentPharmacotherapyDrug Development +3

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

James Sutton, Scott A. Bolton, Malcolm E. Davis, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistrySolid-phase SynthesisMedicinePharmacotherapyDrug Development +3

Synthesis of potent and highly selective inhibitors of human tryptase

William A. Slusarchyk, Scott A. Bolton, Karen S. Hartl, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesHuman Tryptase +7

Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor α Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)

Jun Li, Lawrence J. Kennedy, Yan Shi, +44

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryCrystal StructureOxysterolBiochemistry +12

Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa

Scott I. Klein, Mark Czekaj, Charles J. Gardner, +12

Journal of Medicinal Chemistry

Vitro PotencyPharmacotherapyInitial Structure−activity RelationshipsChemical BiologyPharmaceutical Chemistry +18

Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase

Gregory S. Bisacchi, William A. Slusarchyk, Scott A. Bolton, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesHuman Tryptase +7

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

Ligaya M. Simpkins, Scott A. Bolton, Zulan Pi, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmacologyPharmacotherapyNon-peptide LigandDrug Development +4

Glycosylation of Branched Amino and Nitro Sugars. 2. Synthesis of the Cororubicin Trisaccharide

Lincoln Noecker, Franco Duarte, Scott A. Bolton, +3

The Journal of Organic Chemistry

Bioorganic ChemistryGlycobiologyPolysaccharideNitro SugarsDigitoxose Residues +15

Synthesis of potent and selective 2-azepanone inhibitors of human tryptase

Guohua Zhao, Scott A. Bolton, Chet Kwon, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesHuman Tryptase +5

Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold

Scott A. Bolton, James Sutton, Rushith Anumula, +17

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiaryl Acid ScaffoldBiochemistryMedicine +6