CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Stephanie M. Pyonteck, Leila Akkari, Alberto J. Schuhmacher, +17

Nature Medicine

Neuro-oncologyGliomaMedicineImmunologyCsf-1r Inhibition Alters +6

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

Daniela F. Quail, Robert L. Bowman, Leila Akkari, +6

Science

The Pinene Path to Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol

Paul A. Wender, Neil F. Badham, Simon P. Conway, +12

Journal of the American Chemical Society

BiologyConcise Stereocontrolled SynthesisChemical EngineeringPinene PathEngineering +13

The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor

Paul A. Wender, Neil F. Badham, Simon P. Conway, +19

Journal of the American Chemical Society

BiologyPinene PathEngineeringDonut IconNatural Sciences +10

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

Huasong Lu, Yuhua Xue, Guoying Karen Yu, +11

eLife

ImmunologyMolecular BiologyTumor BiologyI-cdk9 TreatmentSignaling Pathway +16

Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis

Chintan Chhatbar, Claudia N. Detje, Elena Grabski, +14

Cell Reports

Innate Immune SystemViral PathogenesisImmunologyNeuroinflammationInflammation +14

Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor

Young Shin Cho, Julian Levell, Gang Liu, +24

ACS Medicinal Chemistry Letters

Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

James Sutton, Scott A. Bolton, Karen S. Hartl, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentPharmacotherapyDrug Development +3

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

James Sutton, Scott A. Bolton, Malcolm E. Davis, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistrySolid-phase SynthesisMedicinePharmacotherapyDrug Development +3

Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

James J. Li, James Sutton, Alexandra A. Nirschl, +19

Journal of Medicinal Chemistry

Androgen ReceptorPharmacotherapyMedicinal ChemistryPharmacological StudyScaffold Modifications +17