Concepedia

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

James Sutton, Scott A. Bolton, Malcolm E. Davis, Karen S. Hartl, Bruce L. Jacobson, Arvind Mathur, Martin L. Ogletree, William A. Slusarchyk, Robert Zahler, Steven M. Seiler,

Bioorganic & Medicinal Chemistry Letters · 2004 · 63 citations · 18 references

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18

The Protein Data Bank

Helen M. Berman · Nucleic Acids Research · 2000 · 39.8K citations

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Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer.

Lawrence B. Schwartz, T R Bradford · Journal of Biological Chemistry · 1986 · 346 citations · Full text

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Human β-tryptase is a ring-like tetramer with active sites facing a central pore

Pedro José Barbosa Pereira, Andreas Bergner, Sandra Macedo‐Ribeiro et al. · Nature · 1998 · 299 citations

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Tryptase Inhibitors Block Allergen-Induced Airway and Inflammatory Responses in Allergic Sheep

James M. Clark, W M Abraham, Cindy Fishman et al. · American Journal of Respiratory and Critical Care Medicine · 1995 · 208 citations

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Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma

Mamidipudi Thirumala Krishna, Anoop Chauhan, Louise Little et al. · Journal of Allergy and Clinical Immunology · 2001 · 153 citations · Full text

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