Concepedia

Solid-phase Peptide Synthesis

Solid-Phase Peptide Synthesis is a peptide synthesis method in which the growing peptide chain is covalently anchored to an insoluble polymeric support, enabling sequential addition of amino acids through iterative deprotection and coupling steps that facilitate rapid purification by simple filtration.

3.3K

Publications

166.9K

Citations

9.4K

Authors

1.7K

Institutions

Publications per year

2017–2026

424

Variants

Spps

Parents

Publications

3.3K

Peptidotriazoles on Solid Phase:  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides

Christian W. Tornøe, Caspar Christensen, Morten Meldal · The Journal of Organic Chemistry · 2002 · 8.5K citations

, , +12

Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides

E. T. Kaiser, Robert L. Colescott, C.D. Bossinger et al. · Analytical Biochemistry · 1970 · 3.5K citations

, , +10

Solid Phase Peptide Synthesis

John Morrow Stewart · Journal of Macromolecular Science Part A - Chemistry · 1976 · 1.8K citations

, , +13

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Richard A. Houghten · Proceedings of the National Academy of Sciences · 1985 · 1.7K citations · Full text

, , +14

Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system.

James P. Tam · Proceedings of the National Academy of Sciences · 1988 · 1.3K citations · Full text

, , +17

1–5 of 3.3K

Authors

9.4K

  1. FA
    Fernando Alberício

    Universitat de Barcelona, Spain

    169 publications · 9.5K citations

    52

    h-index

  2. GB
    George Bárány

    University of Minnesota, United States

    49 publications · 3.6K citations

    34

    h-index

  3. RB
    R. B. Merrifield

    Rockefeller University, United States

    48 publications · 5.6K citations

    34

    h-index

  4. MM
    Morten Meldal

    Carlsberg Laboratory, Denmark

    56 publications · 10.9K citations

    32

    h-index

  5. RC
    R. C. Sheppard

    MRC Laboratory of Molecular Biology, United Kingdom

    37 publications · 3.6K citations

    31

    h-index

1–5 of 9.4K

Institutions

1.7K

  1. Universitat de Barcelona

    Barcelona, Spain

    50 h-index

    496 publications

    26.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    38 h-index

    537 publications

    20.2K citations

  3. University of Minnesota

    Minneapolis, United States

    37 h-index

    207 publications

    13.2K citations

  4. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

    Madrid, Spain

    30 h-index

    118 publications

    5.1K citations

  5. The University of Melbourne

    Melbourne, Australia

    29 h-index

    194 publications

    8.4K citations

  6. University of KwaZulu-Natal

    Durban, South Africa

    27 h-index

    150 publications

    6.6K citations

  7. Carlsberg Laboratory

    Copenhagen, Denmark

    26 h-index

    94 publications

    29.2K citations

  8. Rockefeller University

    New York, United States

    26 h-index

    105 publications

    11.6K citations

1–8 of 1.7K

Venues

  1. Journal of the American Chemical Society

    JACS · 190 publications · 16.1K citations

    71

    h-index

  2. The Journal of Organic Chemistry

    JOC · 227 publications · 20.5K citations

    60

    h-index

  3. Tetrahedron Letters

    294 publications · 11.7K citations

    53

    h-index

  4. Organic Letters

    OL · 185 publications · 7.8K citations

    47

    h-index

  5. 46

    h-index

1–5