MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation

Kyung‐min Lee, Jennifer M. Giltnane, Justin M. Balko, +16

Cell Metabolism

Tumor BiologyBreast OncologyMitochondrial FunctionMedicineMitochondrial Oxidative Phosphorylation +6

A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia

Haley E. Ramsey, Melissa A. Fischer, Taekyu Lee, +11

Cancer Discovery

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

Anders Friberg, Dominico Vigil, Bin Zhao, +8

Journal of Medicinal Chemistry

Lead CompoundsDrug TargetLarge Fragment LibraryMolecular BiologyChemical Biology +14

Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods

Nicholas F. Pelz, Zhiguo Bian, Bin Zhao, +13

Journal of Medicinal Chemistry

Drug TargetMolecular BiologyTumor BiologyMyeloid NeoplasiaHematological Malignancy +14

Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design

Jason P. Burke, Zhiguo Bian, Subrata Shaw, +11

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetMolecular BiologyHeterocycle ChemistryChemical Biology +16

Discovery of a Tetracyclic Quinoxaline Derivative as a Potent and Orally Active Multifunctional Drug Candidate for the Treatment of Neuropsychiatric and Neurological Disorders

Peng Li, Qiang Zhang, Albert J. Robichaud, +12

Journal of Medicinal Chemistry

Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design

Subrata Shaw, Zhiguo Bian, Bin Zhao, +13

Journal of Medicinal Chemistry

PharmacotherapyPharmaceutical ChemistryTumor BiologyMedicinal ChemistryDrug Design +14

Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer

Taekyu Lee, Plamen P. Christov, Subrata Shaw, +24

Journal of Medicinal Chemistry

Hematological MalignancyTumor BiologyMouse Xenograft ModelsVivo ActivityCompound 42 +13

Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos‐Mediated Activation

Qi Sun, Jason P. Burke, Jason Phan, +6

Angewandte Chemie

Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Jianhua Tian, Kevin B. Teuscher, Erin R. Aho, +22

Journal of Medicinal Chemistry

Molecular DockingCombinatorial ChemistryMedicinal ChemistryWin SiteDrug Target +13