Abran Costales

Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor

Young Shin Cho, Julian Levell, Gang Liu et al. · ACS Medicinal Chemistry Letters · 2017 · 113 citations · Full text

Discovery of Potent and Selective RSK Inhibitors as Biological Probes

Rama Jain, Michelle Mathur, Jiong Lan et al. · Journal of Medicinal Chemistry · 2015 · 82 citations · Full text

Drug Target, Chemoprevention Strategy, Rsk Kinase Family +17

Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors

Savithri Ramurthy, Sharadha Subramanian, Mina Aikawa et al. · Journal of Medicinal Chemistry · 2008 · 76 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Pharmaceutical Science +13

Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma

Teresa E. Williams, Sharadha Subramanian, Joelle Verhagen et al. · ACS Medicinal Chemistry Letters · 2015 · 53 citations · Full text

Medicinal Chemistry, Drug Target, Oncology +15

Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990

Christopher M. McBride, Barry H. Levine, Yi Xia et al. · Journal of Medicinal Chemistry · 2014 · 27 citations · Full text

Structure–activity Relationship, Pharmaceutical Science, Commercial Hit +16