Ellen Rohde

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

Jonathan D. Finn, Amy Smith, Mihir Patel et al. · Cell Reports · 2018 · 801 citations · Full text

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

Kiran Musunuru, Alexandra C. Chadwick, Taiji Mizoguchi et al. · Nature · 2021 · 713 citations

Knockout Mouse, Genetics, Genetic Engineering +8

Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting <i>PCSK9</i> in Nonhuman Primate and Mouse Models

Richard Lee, Anne Marie Mazzola, Maurine Braun et al. · Circulation · 2022 · 186 citations

GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy

Lisa N. Kasiewicz, Souvik Biswas, Aaron Beach et al. · Nature Communications · 2023 · 117 citations · Full text

Nanoparticles, Nanotherapeutics, Engineering +18

A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity

Jianying Dong, Arlene Sereno, Dikran Aivazian et al. · mAbs · 2011 · 78 citations · Full text

Tumor Biology, Single Mabs, Parental Monoclonal Antibodies +14