Bradley K. Wong

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Daria J. Hazuda, Neville J. Anthony, Robert Gomez et al. · Proceedings of the National Academy of Sciences · 2004 · 333 citations · Full text

Life Sciences, Pharmacokinetics, Pharmacology +17

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

Danna Jennings, Sarah Huntwork‐Rodriguez, Anastasia G. Henry et al. · Science Translational Medicine · 2022 · 252 citations

Life Sciences, Neuroscience, Pharmacology +17

A peptide–doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

Deborah Defeo-Jones, Victor M. Garsky, Bradley K. Wong et al. · Nature Medicine · 2000 · 158 citations

Pharmacy, Oncology, Pharmacology +16

Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine:  Discovery of <i>N</i> -[(3 <i>R</i> ,6 <i>S</i> )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 <i>H</i> -imidazo[4,5- <i>b</i> ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

Daniel V. Paone, Anthony W. Shaw, Diem N. Nguyen et al. · Journal of Medicinal Chemistry · 2007 · 146 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells

Daniel Kalman, Bradley K. Wong, Andrew Horvai et al. · Neuron · 1990 · 121 citations

Life Sciences, Cell Biology, Neuroscience +16