MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou, +17

Molecular Cancer Therapeutics

Tumor BiologyInhibitory ActivityMedicineHdac IsotypePharmacology +11

Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin–angiotensin system

Lei Wang, Qing Zhu, Aihua Lu, +6

Journal of Hypertension

FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice

Xuebo Pan, Yihui Shao, Fan Wu, +16

Cell Metabolism

HypertensionCardiovascular DiseaseMedicineAntihypertensive TherapyPhysiology +7

Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity

Oscar Moradei, Tammy C. Mallais, Sylvie Fréchette, +14

Journal of Medicinal Chemistry

Inhibitory ActivityMedicinal ChemistryBioorganic ChemistryBiochemistryUnusual Bis +13

Discovery of <i>N</i>-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor

Nancy Zhou, Oscar Moradei, Stéphane Raeppel, +19

Journal of Medicinal Chemistry

Compound 8Chemoprevention StrategyPharmacotherapyInduces HistoneChemical Biology +16

Sodium butyrate attenuates angiotensin II‐induced cardiac hypertrophy by inhibiting COX2/PGE2 pathway via a HDAC5/HDAC6‐dependent mechanism

Linlin Zhang, Mokan Deng, Aihua Lu, +8

Journal of Cellular and Molecular Medicine

HypertensionHeart FailureHdac6 ActivitiesImmunologyCardiovascular Pharmacology +18

Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4

Fei Wang, Xiaohan Lu, Kexin Peng, +9

Journal of the American Society of Nephrology

Stereospecificity of microsomal and purified epoxide hydrase from rat liver. Hydration of arene oxides of polycyclic hydrocarbons.

Dhiren R. Thakker, H. Yagi, Wayne Levin, +3

Journal of Biological Chemistry

BiochemistryNatural SciencesMedicineOrganic ChemistryPurified Epoxide Hydrase +6

Activation of Renal (Pro)Renin Receptor Contributes to High Fructose-Induced Salt Sensitivity

Chuanming Xu, Aihua Lu, Xiaohan Lu, +4

Hypertension

HypertensionMolecular PharmacologyMetabolic SyndromeRenal FunctionHigh-fructose Intake +19

Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor

Ziwei Fu, Fei Wang, Xiyang Liu, +8

Clinical Science