<i>N</i>-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. <i>N</i>-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent

Raj N. Misra, Hai‐Yun Xiao, Kyoung S. Kim, +23

Journal of Medicinal Chemistry

Chemoprevention StrategyImmunologyPharmacotherapyCdk2/cyce IcPharmaceutical Chemistry +17

Improved method for the preparation of guanidines

Kyoung Soon Kim, Ligang Qian

Tetrahedron Letters

PharmacologySynthesis Method

Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2:  Synthesis, X-ray Crystallographic Analysis, and Biological Activities

Kyoung Soon Kim, S. David Kimball, Raj N. Misra, +27

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetCdk2 ProteinCompound 14Heterocycle Chemistry +18

Discovery of Brivanib Alaninate ((<i>S</i>)-((<i>R</i>)-1-(4-(4-Fluoro-2-methyl-1<i>H</i>-indol-5-yloxy)-5-methylpyrrolo[2,1-<i>f</i>][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), A Novel Prodrug of Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinase Inhibitor (BMS-540215)

Zhen‐Wei Cai, Yongzheng Zhang, R. M. Borzilleri, +21

Journal of Medicinal Chemistry

Pharmaceutical ScienceOral BioavailabilityL-alanine Prodrug 8PharmacotherapyPharmaceutical Chemistry +18

Discovery and Preclinical Studies of (<i>R</i>)-1-(4-(4-Fluoro-2-methyl-1<i>H</i>-indol-5-yloxy)-5- methylpyrrolo[2,1-<i>f</i>][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an In Vivo Active Potent VEGFR-2 Inhibitor

Rajeev S. Bhide, Zhen‐Wei Cai, Yong‐Zheng Zhang, +25

Journal of Medicinal Chemistry

Thio- and Oxoflavopiridols, Cyclin-Dependent Kinase 1-Selective Inhibitors:  Synthesis and Biological Effects

Kyoung Soon Kim, John S. Sack, John S. Tokarski, +11

Journal of Medicinal Chemistry

Flavopiridol AnaloguesPharmacotherapyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +14

Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships

Kyoung Soon Kim, Ligang Qian, J. Eileen Bird, +7

Journal of Medicinal Chemistry

Medicinal ChemistryNovel Quinoxaline HeterocyclePharmacological StudyBiochemistryVs 30 +12

Design, Synthesis, and Evaluation of Orally Active 4-(2,4-Difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-<i>f</i>][1,2,4]triazines as Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Inhibitors

R. M. Borzilleri, Xiaoping Zheng, Ligang Qian, +15

Journal of Medicinal Chemistry

Enzyme KineticsMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +12

Discovery and Evaluation of <i>N</i>-Cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a Selective and Orally Efficacious Inhibitor of Vascular Endothelial Growth Factor Receptor-2

R. M. Borzilleri, Rajeev S. Bhide, Joel C. Barrish, +14

Journal of Medicinal Chemistry

Orally Efficacious InhibitorPharmacotherapyAnalogue 14Tumor BiologyEnzyme Kinetics +17

Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors

R. M. Borzilleri, Zhen‐Wei Cai, Christopher D. Ellis, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineAnti-cancer AgentDrug DevelopmentPharmacology +3