Pseudomonas flavescens sp. nov., Isolated from Walnut Blight Cankers

D. C. Hildebrand, Norberto J. Palleroni, Mavis Hendson, +2

International Journal of Systematic Bacteriology

BiologyMicrobial SystematicsEngineeringBiochemistryBacteriology +11

Certain canine weakly beta-hemolytic intestinal spirochetes are phenotypically and genotypically related to spirochetes associated with human and porcine intestinal spirochetosis

G Duhamel, Nagaraja Muniappa, Michelle R. Mathiesen, +4

Journal of Clinical Microbiology

Parasitic DiseaseSerpulina Type SpeciesIs-associated WbhisPathogenesisType Species +9

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

Timothy B. Durham, James L. Toth, Valentine J. Klimkowski, +18

Journal of Biological Chemistry

Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine

Craig Swearingen, John W. Carpenter, Robert W. Siegel, +13

Osteoarthritis and Cartilage

Biomarker (Medicine)EngineeringAutoimmune DiseaseAggrecanase-generated Aggrecan FragmentsMedicine +11

Discovery of <i>N</i>-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3<i>R</i>)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model

Kevin R. Fales, F. George Njoroge, Harold B. Brooks, +21

Journal of Medicinal Chemistry

PharmacotherapyCancer Xenograft ModelPharmaceutical ChemistryTumor BiologyMolecular Pharmacology +16

Identification of Potent and Selective Hydantoin Inhibitors of Aggrecanase-1 and Aggrecanase-2 That Are Efficacious in Both Chemical and Surgical Models of Osteoarthritis

Timothy B. Durham, Valentine J. Klimkowski, Christopher J. Rito, +11

Journal of Medicinal Chemistry

SclerostinOsteoporosisOrthopaedic SurgeryMusculoskeletal ResearchInflammation +15

A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties

Stanley Kupchinsky, Sara Centioni, Tiffany T. Howard, +14

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryPharmaceutical ScienceBioorganic ChemistryDna Binding +11

Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

Harold B. Brooks, Timothy I. Meier, Sandaruwan Geeganage, +24

Scientific Reports

A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose

Timothy B. Durham, Jothirajah Marimuthu, James L. Toth, +8

Journal of Medicinal Chemistry

Identification of antimicrobial compounds active against intracellular<i>Staphylococcus aureus</i>

François Malouin, Éric Brouillette, Alejandro Martínez Martínez, +4

FEMS Immunology & Medical Microbiology