Craig Swearingen

Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell et al. · Journal of Medicinal Chemistry · 2010 · 97 citations · Full text

Spare Mmp-1, Pharmacotherapy, Pharmaceutical Chemistry +17

Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy

Daniel P. Becker, Clara I. Villamil, Thomas E. Barta et al. · Journal of Medicinal Chemistry · 2005 · 64 citations · Full text

Pharmaceutical Science, Breast Oncology, Immunology +23

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design

Spencer B. Jones, Lance A. Pfeifer, Thomas J. Bleisch et al. · ACS Medicinal Chemistry Letters · 2016 · 46 citations · Full text

Excellent Potency, Pharmaceutical Science, Drug Target +20

Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine

Craig Swearingen, John W. Carpenter, Robert W. Siegel et al. · Osteoarthritis and Cartilage · 2010 · 38 citations · Full text

Biomarker (Medicine), Engineering, Autoimmune Disease +13

α-Amino-β-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 37 citations · Full text

Medicinal Chemistry, Medicine, Potent Mmp-13 Inhibitors +6