Sandra D. Appleby

Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor <i>N</i>-(9-Hydroxy-9-fluorenecarboxy)prolyl <i>trans</i>-4-Aminocyclohexylmethyl Amide (L-372,460):  Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support

Stephen F. Brady, Kenneth J. Stauffer, William C. Lumma et al. · Journal of Medicinal Chemistry · 1998 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Potent Noncovalent Thrombin Inhibitors That Utilize the Unique Amino Acid <scp>d</scp>-Dicyclohexylalanine in the P3 Position. Implications on Oral Bioavailability and Antithrombotic Efficacy

Thomas J. Tucker, William C. Lumma, Sidney D. Lewis et al. · Journal of Medicinal Chemistry · 1997 · 58 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor

Terry A. Lyle, Zhongguo Chen, Sandra D. Appleby et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 39 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Synthesis of a Series of Potent and Orally Bioavailable Thrombin Inhibitors That Utilize 3,3-Disubstituted Propionic Acid Derivatives in the P₃ Position

Thomas J. Tucker, William C. Lumma, Sidney D. Lewis et al. · Journal of Medicinal Chemistry · 1997 · 34 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Inhibition of Thrombin by Peptides Containing Lysyl-α-Keto Carbonyl Derivatives

S.D. Lewis, Assunta S. Ng, Elizabeth A. Lyle et al. · Thrombosis and Haemostasis · 1995 · 32 citations

Medicine, Biochemistry, Pharmacology +17