The Refined Crystal Structure of Cowpea Mosaic Virus at 2.8 Å Resolution

Tianwei Lin, Zhongguo Chen, Ramakrishnan Usha, +4

Virology

Refined Crystal StructureVirus StructureMolecular BiologyVirologyVirus Classification +5

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

Youwei Yan, Ying Li, Sanjeev Munshi, +8

Protein Science

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau, Hans E. Purkey, A. Hitz, +32

Nature Chemical Biology

Systems BiologyBiochemistryLdha InhibitionLipid PeroxidationMetabolic Regulation +6

Refined 2 Å X-ray crystal structure of porcine pancreatic kallikrein A, a specific trypsin-like serine proteinase

Wolfram Bode, Zhongguo Chen, Klaus Bartels, +3

Journal of Molecular Biology

Protein ChemistryProtein SecretionProtein FunctionBiochemistryProtein Assembly +4

Protein-RNA Interactions in an Icosahedral Virus at 3.0 Å Resolution

Zhongguo Chen, Cynthia V. Stauffacher, Yunge Li, +6

Science

Viral ReplicationMolecular BiologyPlant VirologyViral Structural ProteinVirus Structure +15

Refined 2.5 Å X-ray crystal structure of the complex formed by porcine kallikrein A and the bovine pancreatic trypsin inhibitor

Zhongguo Chen, Wolfram Bode

Journal of Molecular Biology

Protein FunctionPorcine KallikreinProtein AssemblyBiochemistryNatural Sciences +3

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)

F. Anthony Romero, Jeremy Murray, Kwong Wah Lai, +40

Journal of Medicinal Chemistry

Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines

Christopher S. Burgey, Kyle A. Robinson, Terry A. Lyle, +32

Journal of Medicinal Chemistry

Pharmaceutical ScienceOral BioavailabilityPharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +16

Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases

Craig A. Coburn, Shawn J. Stachel, Yue‐Ming Li, +20

Journal of Medicinal Chemistry

Protein SecretionProtein AssemblyMolecular BiologyAspartyl ProteasesChemical Biology +14

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

Alexander M. Taylor, Alexandre Côté, Michael C. Hewitt, +41

ACS Medicinal Chemistry Letters

Drug TargetChemical BiologyCancer BiologyMedicinal ChemistryAnti-cancer Agent +14