Reduction in Acquisition of Vancomycin-Resistant Enterococcus after Enforcement of Routine Environmental Cleaning Measures

Mary K. Hayden, Marc J. M. Bonten, Donald Blom, +3

Clinical Infectious Diseases

Risk of Hand or Glove Contamination After Contact With Patients Colonized With Vancomycin-Resistant <i>Enterococcus</i> or the Colonized Patients' Environment

Mary K. Hayden, Donald Blom, Elizabeth A. Lyle, +2

Infection Control and Hospital Epidemiology

Cutting Edge: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects against Leprosy

C. Mark Johnson, Elizabeth A. Lyle, Katherine Omueti Ayoade, +6

The Journal of Immunology

Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus

George Hajishengallis, Richard I. Tapping, Evlambia Harokopakis, +7

Cellular Microbiology

Microbial PathogensImmunologyOral MicrobiologyInnate ImmunityDrug Resistance +19

Domain Exchange between Human Toll-like Receptors 1 and 6 Reveals a Region Required for Lipopeptide Discrimination

Katherine Omueti Ayoade, John M. Beyer, C. Mark Johnson, +2

Journal of Biological Chemistry

Innate Immune SystemImmunologyImmunologic MechanismInnate ImmunityHuman Tlr1 +16

Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines

Christopher S. Burgey, Kyle A. Robinson, Terry A. Lyle, +32

Journal of Medicinal Chemistry

Pharmaceutical ScienceOral BioavailabilityPharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +16

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position

Thomas J. Tucker, Stephen F. Brady, William C. Lumma, +18

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryPharmacotherapyUtilize Nonbasic GroupsChemical Biology +16

The Polymorphism P315L of Human Toll-Like Receptor 1 Impairs Innate Immune Sensing of Microbial Cell Wall Components

Katherine Omueti Ayoade, Daniel J. Mazur, Katherine S. Thompson, +2

The Journal of Immunology

Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Philip E.J. Sanderson, Terry A. Lyle, Kellie J. Cutrona, +21

Journal of Medicinal Chemistry

ThrombosisMedicinal ChemistryPharmacological StudyBiochemistryModest Half-lives +13

Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor <i>N</i>-(9-Hydroxy-9-fluorenecarboxy)prolyl <i>trans</i>-4-Aminocyclohexylmethyl Amide (L-372,460):  Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support

Stephen F. Brady, Kenneth J. Stauffer, William C. Lumma, +16

Journal of Medicinal Chemistry

Combinatorial ChemistryPolystyrene SupportChemical BiologySolid SupportPharmaceutical Chemistry +14