Dennis A. Holt

Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

Tim Clackson, Yang Wu, Leonard W. Rozamus et al. · Proceedings of the National Academy of Sciences · 1998 · 564 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +17

A humanized system for pharmacologic control of gene expression

Victor M. Rivera, Tim Clackson, Sridaran Natesan et al. · Nature Medicine · 1996 · 544 citations

Life Sciences, Molecular Biology, Pharmacology +9

Regulation of Protein Secretion Through Controlled Aggregation in the Endoplasmic Reticulum

Victor M. Rivera, Xiurong Wang, Scott Wardwell et al. · Science · 2000 · 344 citations

Pharmacy, Pharmaceutical Biotechnology, Pharmaceutics +17

A versatile synthetic dimerizer for the regulation of protein–protein interactions

Jane F. Amara, Tim Clackson, Victor M. Rivera et al. · Proceedings of the National Academy of Sciences · 1997 · 206 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

Design, synthesis, and kinetic evaluation of high-affinity FKBP ligands and the X-ray crystal structures of their complexes with FKBP12

Dennis A. Holt, Juan I. Luengo, Dennis S. Yamashita et al. · Journal of the American Chemical Society · 1993 · 204 citations

Natural Sciences, Biochemistry, Medicinal Chemistry +10