Juan I. Luengo

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Steven D. Knight, Nicholas D. Adams, Joelle L. Burgess et al. · ACS Medicinal Chemistry Letters · 2010 · 372 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist

Connie L. Erickson‐Miller, Evelyne Delorme, Shin‐Shay Tian et al. · Stem Cells · 2008 · 286 citations · Full text

Medicine, Hematology, Pharmacology +15

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Melissa B. Pappalardi, Kathryn Keenan, Mark Cockerill et al. · Nature Cancer · 2021 · 280 citations · Full text

Medicine, Oncology, Pharmacology +8

Design, synthesis, and kinetic evaluation of high-affinity FKBP ligands and the X-ray crystal structures of their complexes with FKBP12

Dennis A. Holt, Juan I. Luengo, Dennis S. Yamashita et al. · Journal of the American Chemical Society · 1993 · 204 citations

Natural Sciences, Biochemistry, Medicinal Chemistry +10

A Small, Nonpeptidyl Mimic of Granulocyte-Colony- Stimulating Factor

Shin-Shay Tian, Peter Lamb, Andrew King et al. · Science · 1998 · 154 citations

Life Sciences, Immunology, Molecular Biology +16