Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

Sharad K. Verma, Xinrong Tian, Louis V. LaFrance, +24

ACS Medicinal Chemistry Letters

Histone ModificationsDrug Discovery ProgramEngineeringEpigenetic ChangeCell-active Inhibitors +16

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Steven D. Knight, Nicholas D. Adams, Joelle L. Burgess, +28

ACS Medicinal Chemistry Letters

Highly Potent InhibitorTumor BiologyMammalian TargetSignaling PathwayCancer Cell Biology +14

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Kenneth W. Wood, Latesh Lad, Lusong Luo, +32

Proceedings of the National Academy of Sciences

Antitumor ActivityCenp-e Motor ActivityMolecular BiologyCell DeathCytoskeleton +16

Synthesis applications of cationic aza-Cope rearrangements. 26. Enantioselective total synthesis of (-)-strychnine

Steven D. Knight, Larry E. Overman, Garry Pairaudeau

Journal of the American Chemical Society

Cationic Aza-cope RearrangementsChemical AnalysisNatural SciencesDiversity-oriented SynthesisAltmetric Attention Score +11

Asymmetric Total Syntheses of (-)- and (+)-Strychnine and the Wieland-Gumlich Aldehyde

Steven D. Knight, Larry E. Overman, Garry Pairaudeau

Journal of the American Chemical Society

EngineeringChemical AnalysisAltmetric Attention ScoreOrganic ChemistryChemistry +15

Synthesis applications of cationic aza-Cope rearrangements. 24. The aza-Cope-Mannich approach to Strychnos alkaloids. Short stereocontrolled total syntheses of (.+-.)-dehydrotubifoline and (.+-.)-akuammicine

Steven R. Angle, John M. Fevig, Steven D. Knight, +2

Journal of the American Chemical Society

Cationic Aza-cope RearrangementsEngineeringBiochemistryNatural SciencesAltmetric Attention Score +10

Novel ATP-Competitive Kinesin Spindle Protein Inhibitors

Cynthia A. Parrish, Nicholas D. Adams, Kurt R. Auger, +25

Journal of Medicinal Chemistry

Protein FunctionBiochemistryMedicineMacromolecular MachineSpindle Pole Separation +13

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

Hongfang Yang, Patrícia Flores de Medeiros, Kaushik Raha, +18

ACS Medicinal Chemistry Letters

Molecular DockingDrug TargetBiochemistryStructural BioinformaticsMedicine +13

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295

Xiangping Qian, Andrew McDonald, Han-Jie Zhou, +46

ACS Medicinal Chemistry Letters

Molecular BiologyNew GenerationCancer BiologyPharmaceutical ChemistryMedicinal Chemistry +17

Signaling function of PRC2 is essential for TCR-driven T cell responses

Marc‐Werner Dobenecker, Joon Seok Park, Jonas Marcello, +7

The Journal of Experimental Medicine

Histone ModificationsAdaptive Immune SystemEpigenetic ChangeT-regulatory CellImmunology +18