Brian W. Metcalf

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

Brian W. Metcalf, Philippe Bey, Charles Danzin et al. · Journal of the American Chemical Society · 1978 · 1K citations

Life Sciences, Pharmacology, Biocatalysis +16

γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE¹

Michael J. Jung, Bruce Lippert, Brian W. Metcalf et al. · Journal of Neurochemistry · 1977 · 479 citations

Life Sciences, Biochemistry, Pharmacology +17

4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian Brain

Bruce Lippert, Brian W. Metcalf, Michel J. Jung et al. · European Journal of Biochemistry · 1977 · 379 citations · Full text

Life Sciences, Biochemistry, Biocatalysis +15

Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor.

Christine Debouck, Joselina Gorniak, James E. Strickler et al. · Proceedings of the National Academy of Sciences · 1987 · 277 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

<scp>GBT</scp>440 increases haemoglobin oxygen affinity, reduces sickling and prolongs <scp>RBC</scp> half‐life in a murine model of sickle cell disease

Donna Oksenberg, Kobina Dufu, Mira Patel et al. · British Journal of Haematology · 2016 · 235 citations · Full text

Medicine, Hematology, Pharmacokinetics +17