Mira Patel

<scp>GBT</scp>440 increases haemoglobin oxygen affinity, reduces sickling and prolongs <scp>RBC</scp> half‐life in a murine model of sickle cell disease

Donna Oksenberg, Kobina Dufu, Mira Patel et al. · British Journal of Haematology · 2016 · 232 citations · Full text

Vitro Hbs Polymerization, Immunology, Selective Partitioning +19

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

Brian Metcalf, Chih-Yuan Chuang, Kobina Dufu et al. · ACS Medicinal Chemistry Letters · 2017 · 183 citations · Full text

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease

Jo Howard, Claire Hemmaway, Paul Telfer et al. · Blood · 2019 · 110 citations · Full text

Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease

Athiwat Hutchaleelaha, Mira Patel, Carla Washington et al. · British Journal of Clinical Pharmacology · 2019 · 95 citations · Full text

GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions

Kobina Dufu, Mira Patel, Donna Oksenberg et al. · Clinical Hemorheology and Microcirculation · 2018 · 86 citations · Full text