Philippe Bey

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

Brian W. Metcalf, Philippe Bey, Charles Danzin et al. · Journal of the American Chemical Society · 1978 · 1K citations

Life Sciences, Pharmacology, Biocatalysis +16

Anti-proliferative properties of DL-α-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase

Pierre S. Mamont, Marie-Christine Duchesne, Jeffrey Grove et al. · Biochemical and Biophysical Research Communications · 1978 · 400 citations

Life Sciences, Biochemistry, Pharmacology +11

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

Hikaru Sugimoto, Valerie S. LeBleu, Dattatreyamurty Bosukonda et al. · Nature Medicine · 2012 · 226 citations · Full text

Medicine, Cell Biology, Nephrology +14

Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites.

R. Poulin, Li‐Fan Lu, Bradley L. Ackermann et al. · Journal of Biological Chemistry · 1992 · 217 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture.

Pierre S. Mamont, Peter Böhlen, Peter P. McCann et al. · Proceedings of the National Academy of Sciences · 1976 · 213 citations · Full text

Life Sciences, Biochemistry, Cell Biology +11