Douglas L. Gernert

Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism

Akihiko Kato, Kevin D. Burris, Kevin M. Gardinier et al. · Nature Medicine · 2016 · 88 citations · Full text

Synaptic Transmission, Neurotransmitter, Neuromodulation Therapies +18

Perampanel, an Antagonist of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors, for the Treatment of Epilepsy: Studies in Human Epileptic Brain and Nonepileptic Brain and in Rodent Models

Ruud Zwart, Emanuele Sher, Xingjie Ping et al. · Journal of Pharmacology and Experimental Therapeutics · 2014 · 68 citations

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8

Kevin M. Gardinier, Douglas L. Gernert, Warren J. Porter et al. · Journal of Medicinal Chemistry · 2016 · 58 citations · Full text

Motor Impairment, Synaptic Transmission, Neuromodulation Therapies +25

(<i>S</i>)-<i>N</i>-{3-[1-Cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1<i>H</i>-indol-7-yl}-methanesulfonamide: A Potent, Nonsteroidal, Functional Antagonist of the Mineralocorticoid Receptor

Michael G. Bell, Douglas L. Gernert, Timothy A. Grese et al. · Journal of Medicinal Chemistry · 2007 · 45 citations · Full text

Hypertension, Functional Antagonist, Pharmacotherapy +16

Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential

Rieko Tanaka, Almudena Rubio, Nancy K. Harn et al. · Bioorganic & Medicinal Chemistry · 2006 · 35 citations

Combinatorial Chemistry, Medicinal Chemistry, Piperidine Farnesyltransferase Inhibitors +8