Activation of the GLP-1 receptor by a non-peptidic agonist

Peishen Zhao, Yi-Lynn Liang, Matthew J. Belousoff, +17

Nature

Molecular PharmacologyMolecular PhysiologySignal TransductionG Protein-coupled ReceptorMedicine +6

Pharmacological characterization of LY335979: A potent cyclopropyldibenzosuberane modulator of P-glycoprotein

James J. Starling, Robert L. Shepard, Jin Cao, +11

Advances in Enzyme Regulation

Molecular PharmacologyPharmacological CharacterizationBiochemistryMedicineGlycobiology +4

A comparative study of the in vitro permeation of ibuprofen in mammalian skin, the PAMPA model and silicone membrane

Lin Luo, Avnish Patel, Bálint Sinkó, +4

International Journal of Pharmaceutics

Pharmaceutical ScienceMedicineLocal PharmacologyPampa ModelSilicone Membrane +8

Ethyl (3<i>S</i>,4a<i>R</i>,6<i>S</i>,8a<i>R</i>)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester:  A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Sandra Filla, Mark A. Winter, Kirk W. Johnson, +21

Journal of Medicinal Chemistry

Diethyl EsterPharmacotherapyExperimental Pharmacology4-Ethoxycar- Bonylimidazol-1-ylmethylMolecular Pharmacology +20

Early results using a dynamic method for delayed primary closure of fasciotomy wounds

Rebecca C. Taylor, Bert J Reitsma, Sue Sarazin, +1

Journal of the American College of Surgeons

(<i>S</i>)-<i>N</i>-{3-[1-Cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1<i>H</i>-indol-7-yl}-methanesulfonamide: A Potent, Nonsteroidal, Functional Antagonist of the Mineralocorticoid Receptor

Michael G. Bell, Douglas L. Gernert, Timothy A. Grese, +14

Journal of Medicinal Chemistry

HypertensionFunctional AntagonistPharmacotherapyChemical BiologyIndole Analogs +14

Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

Esteban Domı́nguez, Smriti Iyengar, Harlan E. Shannon, +24

Journal of Medicinal Chemistry

Pain TherapyPain MedicineNeuropathic PainMolecular PainPharmacotherapy +17

Behaviour and sun exposure in holidaymakers alters skin microbiota composition and diversity

Thomas Willmott, Paul M. Campbell, C.E.M. Griffiths, +5

Frontiers in Aging

Microwave assisted synthesis of triazolobenzoxazepine and triazolobenzoxazocine heterocycles

Aubrey J. Ellison, Robert D. Boyer, Paul Hoogestraat, +1

Tetrahedron Letters

Organic ChemistryTriazolobenzoxazocine HeterocyclesSynthesis MethodHeterocycle ChemistryMicrowave Synthesis

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

José Antonio Martínez-Pérez, Smriti Iyengar, Harlan E. Shannon, +24

Bioorganic & Medicinal Chemistry Letters

Pharmaceutical ScienceMedicinePain MedicineVitro ProfilePharmacological Agent +6