Karen S. Chen

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( <i>SMN2</i> ) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Hasane Ratni, Martin Ebeling, John D. Baird et al. · Journal of Medicinal Chemistry · 2018 · 520 citations · Full text

Medicine, Neurology, Pharmacology +14

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

Fred H. Gage, Peter Batchelor, Karen S. Chen et al. · Neuron · 1989 · 241 citations

Life Sciences, Neurobiology, Neuroscience +16

Human amnesia and animal models of amnesia: Performance of amnesic patients on tests designed for the monkey.

Larry R. Squire, Stuart Zola‐Morgan, Karen S. Chen · Behavioral Neuroscience · 1988 · 227 citations

Social Sciences, Neuroscience, Psychology +15

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)

Atwood K. Cheung, Brian Hurley, Ryan Kerrigan et al. · Journal of Medicinal Chemistry · 2018 · 132 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Candidate Proteins, Metabolites and Transcripts in the Biomarkers for Spinal Muscular Atrophy (BforSMA) Clinical Study

Richard S. Finkel, Thomas O. Crawford, Kathryn J. Swoboda et al. · PLoS ONE · 2012 · 86 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17