Ayako Nogami

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia

Ayako Nogami, Gaku Oshikawa, Keigo Okada et al. · Oncotarget · 2015 · 64 citations · Full text

Medicine, Oncology, Pharmacology +16

FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM

Daisuke Watanabe, Ayako Nogami, Keigo Okada et al. · Cancers · 2019 · 49 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress

Hiroki Akiyama, Yoshihiro Umezawa, Shinya Ishida et al. · Cancer Letters · 2019 · 36 citations

Life Sciences, Cancer Biology, Molecular Biology +13

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway

Keigo Okada, Ayako Nogami, Shinya Ishida et al. · Oncotarget · 2017 · 35 citations · Full text

Medicine, Oncology, Pharmacology +16

Proliferation and Survival Signaling from Both Jak2-V617F and Lyn Involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 Cell Line Newly Established from Acute Myeloid Leukemia Transformed from Polycythemia Vera

Toshikage Nagao, Tetsuya Kurosu, Yoshihiro Umezawa et al. · PLoS ONE · 2014 · 25 citations · Full text

Medicine, Hematology, Molecular Biology +17