Hiroki Akiyama

High‐dose methotrexate following intravitreal methotrexate administration in preventing central nervous system involvement of primary intraocular lymphoma

Hiroki Akiyama, Hiroshi Takase, Fumito Kubo et al. · Cancer Science · 2016 · 92 citations · Full text

FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM

Daisuke Watanabe, Ayako Nogami, Keigo Okada et al. · Cancers · 2019 · 46 citations · Full text

Immunology, Cell Death, Cancer Biology +17

Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia

Hiroki Akiyama, Ran Zhao, Lauren B. Ostermann et al. · Leukemia · 2023 · 40 citations · Full text

Redox Signaling, Mitochondrial Function, Biochemistry +9

Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress

Hiroki Akiyama, Yoshihiro Umezawa, Shinya Ishida et al. · Cancer Letters · 2019 · 36 citations

Reductive Stress, Mutant Kinase, Apoptosis +9

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway

Keigo Okada, Ayako Nogami, Shinya Ishida et al. · Oncotarget · 2017 · 35 citations · Full text

Hematological Malignancy, Cancer Research, Signal Transduction +15