High‐dose methotrexate following intravitreal methotrexate administration in preventing central nervous system involvement of primary intraocular lymphoma

Hiroki Akiyama, Hiroshi Takase, Fumito Kubo, +6

Cancer Science

FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM

Daisuke Watanabe, Ayako Nogami, Keigo Okada, +3

Cancers

ImmunologyCell DeathCancer BiologyTumor BiologyNegative Feedback Regulation +15

Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia

Hiroki Akiyama, Ran Zhao, Lauren B. Ostermann, +15

Leukemia

Redox SignalingMitochondrial FunctionBiochemistryNatural SciencesHematology +7

Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress

Hiroki Akiyama, Yoshihiro Umezawa, Shinya Ishida, +3

Cancer Letters

Reductive StressMutant KinaseApoptosisAutophagyImmunology +7

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway

Keigo Okada, Ayako Nogami, Shinya Ishida, +4

Oncotarget

Hematological MalignancyCancer ResearchSignal TransductionPim KinasesPi3k/akt Pathway Inhibitors +13

High‐resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays

Ludan Wang, Aiko Sato‐Otsubo, Sunao Sugita, +9

Cancer Science

Effusion and solid lymphomas have distinctive gene and protein expression profiles in an animal model of primary effusion lymphoma

Yuka Yanagisawa, Yuko Sato, Yasuko Asahi‐Ozaki, +11

The Journal of Pathology

Primary Effusion LymphomaSolid LymphomaImmunologyPathologyAntigen Processing +18

Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2

Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, +5

Oncotarget

MitophagyAutophagy InhibitorsMixed-phenotype Acute LeukemiaApoptosisImmunology +22

Enhancement of Critical Current Densities in (Ba,K)Fe₂As₂by 320 MeV Au Irradiation in Single Crystals and by High-Pressure Sintering in Powder-in-Tube Wires

Sunseng Pyon, Toshihiro Taen, Fumiaki Ohtake, +7

Applied Physics Express

Metal-to-insulator transition in anatase TiO2 thin films induced by growth rate modulation

Takashi Tachikawa, Makoto Minohara, Yoshinobu Nakanishi, +5

Applied Physics Letters

Materials ScienceMaterial AnalysisEngineeringNanotechnologyOptical Properties +13