Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Catherine C. Smith, Qi Wang, Chen-Shan Chin et al. · Nature · 2012 · 745 citations

Medicine, Genetics, Hematology +13

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

Martin Schwickart, Xiaodong Huang, Jennie R. Lill et al. · Nature · 2009 · 620 citations

Medicine, Cancer Biology, Oncology +13

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

Fabien Llambi, Tudor Moldoveanu, Stephen W. G. Tait et al. · Molecular Cell · 2011 · 579 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Pádraig D’Arcy, Slavica Brnjic, Maria Hägg Olofsson et al. · Nature Medicine · 2011 · 497 citations · Full text

Life Sciences, Molecular Biology, Oncology +14

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

Vaibhav Kapuria, Luke F. Peterson, Dexing Fang et al. · Cancer Research · 2010 · 395 citations

Medicine, Cancer Biology, Oncology +13