Gaku Oshikawa

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia

Ayako Nogami, Gaku Oshikawa, Keigo Okada et al. · Oncotarget · 2015 · 63 citations · Full text

c-Cbl and Cbl-b Ligases Mediate 17-Allylaminodemethoxygeldanamycin-induced Degradation of Autophosphorylated Flt3 Kinase with Internal Tandem Duplication through the Ubiquitin Proteasome Pathway

Gaku Oshikawa, Toshikage Nagao, Nan Wu et al. · Journal of Biological Chemistry · 2011 · 45 citations · Full text

Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway

Tetsuya Kurosu, Nan Wu, Gaku Oshikawa et al. · APOPTOSIS · 2010 · 42 citations

Bcr/abl-expressing Cells, Mitophagy, Mitochondrial Function +11

Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhances Induction of Apoptosis

Tetsuya Kurosu, Toshikage Nagao, Nan Wu et al. · PLoS ONE · 2013 · 40 citations · Full text

G2/m Arrest, Tyrosine Kinase, Apoptosis +17

Proliferation and Survival Signaling from Both Jak2-V617F and Lyn Involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 Cell Line Newly Established from Acute Myeloid Leukemia Transformed from Polycythemia Vera

Toshikage Nagao, Tetsuya Kurosu, Yoshihiro Umezawa et al. · PLoS ONE · 2014 · 25 citations · Full text